However, in contrast to our previous findings in PD and AD rodent models in which DN-TNF peptide was directly infused [18], [19] or expressed via lentivirus [18], [20], [41], single bilateral injections of AAV-DN-TNF delivery did not rescue degenerating MSNs in YAC128 TG mice compared to AAV-GFP. This evidence concerns the gene TNF and Alzheimer disease.