Moreover, inhibition of p38 signaling was associated with a defect in global genome nucleotide excision repair (GG-NER), a vitally important tumor protective pathway that recognizes and excises UVB-induced CPDs (cyclobutane pyrimidine dimers) and 6-4PPs (pyrimidine (6-4) pyrimidone photoproducts) that would otherwise be mutagenic [36]. The gene discussed is MAPK14; the disease is neoplasm.