Furthermore, in a subgroup analysis of high-grade (Gleason 4 and 5) PCa, there was statistically significant upregulation of nuclear hnRNPA2 compared with low-grade (Gleason 3) PCa (P = 0.011), and BPH controls (P = 0.003). This evidence concerns the gene HNRNPA2B1 and posterior cortical atrophy.