In support of this, when we compared our TP53/TP63 regulated genes with microarray data from tumours and matched normal in two independent head and neck squamous cell carcinoma cohorts (51,52), we found that there was significant enrichment for increased expression of genes that are TP53 repressed, whereas no significant enrichment was observed for TP53-induced genes. The gene discussed is TP63; the disease is neoplasm.