Trp53 knockout mice and patients with germline TP53 mutations (Li-Fraumeni syndrome—LFS) (4,5) are highly cancer prone, whereas Trp63 deficiency is perinatally lethal (3,6) due to a lack of skin and other developmental defects that are shared by patients with a spectrum of syndromes associated with TP63 mutations (7). This evidence concerns the gene TP53 and cancer.