These included genes encoding proteins involved in homologous recombination (HR)/Fanconi Anemia (FA) pathway (RAD51B, BRCA1, FANCD2, BRCA2), Non-Homologous end Joining (e.g. XRCC4) and mismatch repair (e.g. MSH2) (Figure 5A). The gene discussed is BRCA1; the disease is Fanconi anemia.