MPLA analysis revealed that a previously unreported heterozygous deletion of CDC73 exons 1–10 is the cause of PHPT in this three-generation family, thereby highlighting the need for performing CDC73 deletion analysis in parathyroid carcinoma patients, and FIHP and HPT-JT families who do not have point mutations of CDC73. This represents the fourth report of a CDC73 deletion. Here, CDC73 is linked to parathyroid gland carcinoma.