Whole CDC73 deletions have been previously reported in a 25-year-old Portuguese man with severe, sporadic PHPT due to a single parathyroid adenoma (17) and a Spanish HPT-JT family, in which the index patient was an 18-year-old female who had jaw tumors and PHPT due to an adenoma that stained negative for parafibromin (13). This evidence concerns the gene CDC73 and parathyroid gland adenoma.