When it comes to clinical neurological manifestation, aβ2GP I links to ischemia events [15, 16] and also a few case reports associated anti-phospholipid antibodies (including aβ2GP I, aCL-IgM, and aCL-IgG) with autoimmune optic neuropathy [17] and cerebellar ataxia [18–21]. Here, CD40LG is linked to aceruloplasminemia.