Bioinformatics suggested that the top biological function activated in WD + AF versus WD rats included: ‘Increased Concentration of Lipid’ (Ahr, Cd36, Efna5, Foxa2, Nr0b2, Pck1, Slc2a2 were up- or down-regulated with WD + AF/CTL and did not change with WD/CTL; categorical function p-value ranges = 4.11E-8 to 2.32E-9). The gene discussed is EFNA5; the disease is atrial fibrillation.