CD8A and neoplasm: In most patients with CLL, there is an increase in both CD8+ and CD4+ T-cell numbers and reversal of CD4/CD8 ratio; however, it has been suggested that the T cell in B-CLL may be unable to start, maintain, and complete an immune response to the malignant B cell and other antigens, the result being susceptibility to infections and sustenance of the tumor [4].