In fact, a suggestive local interaction pair of rs2725227 and rs2725222 (distance = 14 kb, Pint was 1.2E−05 in ARIC and 9.6E−03 in FHS) was near ABCG2, with both SNPs were located in PKD2, a candidate causal locus of polycystic kidney disease (41) and regulator of SUA levels (42). The gene discussed is PKD2; the disease is polycystic kidney disease.