Conventional GWAS identified 166 genome-wide significant (P < 5.0E−08) SNP associations in ARIC (Supplementary Material, Table S2 and Fig. S1) and 75 in FHS (Supplementary Material, Table S3 and Fig. S2), allocated mostly to the SLC2A9-WDR1 (4p16.1) and ABCG2 regions (4q22) in both cohorts. Here, WDR1 is linked to Floating-Harbor syndrome.