A study by Chen et al. [104] demonstrated that CD133+, EpCAM+ cells, showed similar properties as tumor initiating cells (TICs) in Huh-7 cells, such as high differentiation capacity, increased potential of colony-formation, preferential expression of stem cell-related genes, MDR to some chemotherapeutics, more spheroid formation in cell cultures and higher tumorigenicity in NOD/SCID mice. The gene discussed is PROM1; the disease is neoplasm.