CDKN2A and head and neck squamous cell carcinoma: However, p16INK4a overexpression indicated the presence of HPV E6/E7 mRNA expression with high sensitivity at 90.5% (19/21) and high specificity at 91.3% (116/127) in HNSCC, and was even more accurate for OPSCC, with sensitivity at 94.4% (17/18) and specificity at 91.4% (32/35) (Table IV).