CDKN2A and head and neck squamous cell carcinoma: In the present study, the sensitivity of general p16INK4a expression for detecting HPV DNA in HNSCC was also low, and there was generally low rate of agreement between p16INK4a-positive status and HR-HPV E6/E7 mRNA expression in both HNSCC (κ=0.56) and OPSCC (κ=0.57).