Four SNPs were associated with the total prevalence of established/advanced nephropathy at the end of follow-up: OR 4.24, 95% CI 1.86–10.68, p = 0.0004 for rs2758329, OR 4.19, 95% CI 1.85–10.54, p = 0.0004 for rs8031, OR 0.30, 95% CI 0.11–0.72, p = 0.009 for rs5746136, and OR 4.01, 95% CI 1.80–9.88, p = 0.0005 for rs4880 OR for the major alleles in a codominant model adjusted for sex, age, duration of diabetes, treatment by ACE inhibitors, and diabetic retinopathy stages). This evidence concerns the gene ACE and diabetic retinopathy.