CD40LG and Autoimmunity: To the best of our knowledge, this is the first time that circulating antigen-specific mBc and antigen-specific Abs of the IgA and IgG1 isotypes are determined in patients receiving B-cell depletion therapy with RTX, and the first time that a correlation between several IgM+ mBc subsets and total plasma IgM is described in patients with autoimmunity.