The minor allele (T) of DRD2 rs1076560 (G/T), located within intron 6 of DRD2, is associated with reduced expression of D2S in prefrontal cortex and striatum, and with altered activity of the striato-thalamic-prefrontal pathway during working memory in healthy subjects [45] and patients with schizophrenia [46]. Here, DRD2 is linked to schizophrenia.