For example, hepatic mRNA expression of IFN-stimulated genes (ISGs, such as ISG15, OAS, IFI, IP10, and viperin) and IFN-related pathway genes (MX and USP18) correlate with responses to peg-IFNα/RBV combination therapy for CH-C [4]–[7]. Here, IFNA1 is linked to cryohydrocytosis.