However, despite the inhibitory influence of TP on proliferation and migration of NSCLC cells in vitro, we show that in vivo the overexpression of the enzyme tended to accelerate tumor growth and increase local metastasis which was associated with significant upregulation of proinflammatory cytokines, interleukin-8 and better oxygenation of tumors. Here, CXCL8 is linked to neoplasm.