Previous studies demonstrated that c-Src and Fyn interact with and phosphorylate the cytoplasmic tail of CD133 in medulloblastoma stem cells (28), and it is possible that Fyn, c-Src and Yes directly interact with CD133 in GSCs; however inhibiting SFKs by dasatinib did not alter CD133 expression patterns in GSC lines. This evidence concerns the gene PROM1 and medulloblastoma.