The top (uncorrected) significant SNPs were located in BAK1, IGF1R, P53AIP1, PMAIP1, SERPINB5, and TP73. Common variants in these genes have not previously been reported as associated with UCB risk, though an altered expression of BAK1 and IGF1R has been described in bladder tumors. This evidence concerns the gene SERPINB5 and urinary bladder neoplasm.