In a recent study, the plasma plasmin-α2-anti-plasmin complex (PAP) was associated with diabetic retinopathy and sight threatening diabetic retinopathy in Type 2 diabetics [10], and correlation was still significant after adjustments of the groups for age, gender, race, the study center, SBP, the use of diabetes medications, disease duration, HbA1c, and waist-to-hip ratio were made [25, 26]. Here, PLG is linked to diabetic retinopathy.