CCN2 and glomerulosclerosis: Cordyceps sinensis (Cordyceps Mushroom) is a valued tonic herb to treat a wide range of disorders, including respiratory, renal, liver, and cardiovascular diseases, low libido and impotence, and hyperlipidemia [97]. Cordyceps sinensis has been shown to ameliorate glomerular sclerosis by reducing proteinuria, decreasing the expressions of fibronectin (FN), collagen-IV, connective tissue growth factor (CTGF), and plasminogen activator inhibitor 1 (PAI-1), and increasing the expression of matrix metalloproteinase-2 (MMP-2) [98].