The extract of Ginkgo biloba (Ginkgo) leaf has shown protective action on early DN through significantly decreased urinary microalbumin (mALB), alpha1-microglobulin (alpha1-MG), immunoglobulin (IgG), transferrin (TF), retinal binding protein (RBP), and N-acetyl-beta-D-glucosaminidase (NAG) [88]. Ginkgo biloba extract injection has also been shown to be effective in treating early DN through decreasing urinary albumin excretion rate, regulating blood lipids, improving renal function, and hemorheology [89]. The gene discussed is OGA; the disease is liver dysplastic nodule.