With semiquantitative RT-PCR, we had found out that PME downregulated the transcription of MMP-9 suggesting its possible role in the inhibition of tumor invasion (Figure 2) whereas E2 (10 nM) did not significantly affect the transcription of MMP-9 [53] which correlated with earlier studies suggesting that estrogen stimulated MMP-9 secretion without increasing its gene transcription [54]. Here, MMP9 is linked to neoplasm.