PTGES and denture stomatitis: Larrosa et al. showed that pomegranate extract supplementations led to reduced prostaglandin E2 (PGE2) levels in the colon mucosa by downregulating the overexpressed COX-2 and prostaglandin E synthase (PTGES) levels owing to the action of ellagic acid [78]. Punica granatum extract had been found to be particularly effective for controlling oral inflammation, dental plaque, and bacterial and fungal counts in periodontal disease and Candida-associated denture stomatitis [81, 82].