The endothelial cell isoform of nitric oxide synthase (eNOS) protected against stroke through BDNF upregulation [37]; eNOS knockout mice exhibited more severe deficits than wild-type mice following permanent right MCAO, as well as reduced progenitor cell proliferation and migration from the SVZ and decreased angiogenesis at the ischemic boarder. The gene discussed is BDNF; the disease is Stroke.