Although the three selected genes are neither clustered directly in any identified signaling pathway nor confirmed to be copresent in any cancer network, our limited but insightful analysis showed high correlations for the mRNA expressions among the three genes in breast cancer, between PIK3C3 and PTEN in ovary cancer, and between PIM3 and PTEN in kidney, liver, and thyroid cancers during disease progression. The gene discussed is PIK3C3; the disease is breast carcinoma.