CD4 and Autoimmunity: During induction of murine mercury-induced autoimmunity (mHgIA) DAF1 is specifically reduced on CD4+ T cells resulting in an accumulation of activated (CD44highDaflow) CD4+ T cells [24]. Daf1 deficiency also exacerbates mHgIA via increased levels of IFN-γ, IL-2, IL-4, and IL-10 but not IL-17 [26].