A detailed structural and conformational dynamics analysis was conducted for major mutational hotspots of kinase-activating and kinase-dead mutations, namely, (a) conserved hotspots corresponding to activating cancer mutants L858R and L861Q in EGFR and (b) a conserved hotspot corresponding to the catalytic Asp residue from the DFG motif implicated in kinase-dead mutations in BRAF, DAPK3, HCK, and LYN (Table 1). Here, EGFR is linked to cancer.