Based on these findings, we embarked on a detailed comparative analysis of activating and inactivating mutations on structure and dynamics of various kinase genes including EGFR, BRAF, FGFR2, FGFR3, MAP2K4, EPHA3, DAPK3, and TRKB kinases (Table 2) and we propose that structural and dynamic signatures of cancer mutations may provide a clue to the underlying mechanism of kinase activation. The gene discussed is DAPK3; the disease is cancer.