TNNT1 and dilated cardiomyopathy: Up to date, at least five cardiac TnT mutants: R131W (Mogensen et al., 2004), R141W (Li et al., 2001), R205L (Mogensen et al., 2004), Lys210 deletion (Kamisago et al., 2000), and D270N (Mogensen et al., 2004), all in the conserved core structure of cardiac TnT, are found to reduce Ca2+ sensitivity and produce phenotypes of dilated cardiomyopathy (Mirza et al., 2005).