TNNT1 and heart failure: Several new phosphorylation sites in the N-terminal region (Ser5/Ser6/Tyr26) have also been identified with decreased phosphorylation in heart failure, whereas phosphorylation of Ser166/Thr181/Ser199 in the C-terminal region and Ser77/Thr78 at the TnI-TnT interface (I-T arm) was increased (Zhang et al., 2012).