Yeast two-hybrid studies indicated that cardiac TnT-ΔK210 bound stronger to cardiac TnI than that of wild type cardiac TnT (Sfichi-Duke et al., 2010), suggesting a possible explanation for cardiac TnT-ΔK210 mutation to correlate with dilated cardiomyopathy (Kamisago et al., 2000). This evidence concerns the gene TNNT1 and dilated cardiomyopathy.