Mutations in different regions of cardiac TnT may contribute to the pathogenesis of cardiomyopathies via different mechanisms, including increasing the Ca2+-sensitivity of troponin complex, changing the binding affinity of cardiac TnT for cardiac TnI and the affinity of cardiac TnI for cardiac TnC, and perturbing the proper response of myocardial contraction to changes in pH (Harada and Potter, 2004). This evidence concerns the gene TNNT1 and cardiomyopathy.