Diabetes also induced a significant increase in Bid levels (173.57 ± 22.64% of control; P < 0.01) comparatively to nondiabetic ZDF (+/+) rats, which was prevented in diabetic rats under sitagliptin treatment (113.02 ± 9.43%; P < 0.05) (Figure 6(c)). Here, BID is linked to diabetes mellitus.