At the beginning of the study (20-week-old animals), the blood glucose levels of diabetic ZDF rats (304.60 ± 9.10 mg/dL) were already significantly higher than those of the age-matched controls (92.30 ± 2.50 mg/dL; P < 0.001); hyperglycemia was accompanied by a decline in insulin secretion, as previously reported [44]. The gene discussed is INS; the disease is Hyperglycemia.