The two UCL BPAD TACR1 markers are not in LD with the PGC ADHD and BPAD SNPs, rs4614953 and rs2422090, or the SNP, rs6715729, associated with ADS (data not shown), suggesting that independent genetic risk factors in TACR1 predict affective disorder phenotypes. The gene discussed is TACR1; the disease is attention deficit-hyperactivity disorder.