The suppressed osteoblast activity not only increases the ratio of RANKL to osteoprotegerin (OPG), enhancing osteoclastogenesis and bone resorption, but also stimulates antiapoptotic factors and growth factors for MM cells, which form a positive feedback between osteoblast suppression and the growth of MM cells 1,3. Here, TNFSF11 is linked to Miyoshi myopathy.