After adjustment for age, BMI, BMD, a history of two or more falls, current smoking, current drinking, previous fractures, hypertension, diabetes, total cholesterol, myocardial infarction, stroke, adiponectin, osteocalcin, leptin, and 25(OH)D, it was interesting that an ACS of G4, BMD, age and a history of two or more falls were associated with non-vertebral fractures. The gene discussed is LEP; the disease is diabetes mellitus.