Particularly, tumor specimens of treatment failures revealed significantly lower ERCC1 expression (staining index 28 ± 30 %; mean ± SD) than specimens from controls (58 ± 40 %; p = 0.0064), while specimens from treatment responders (48 ± 35 %) did not (p > 0.05) (Fig. 1). Here, ERCC1 is linked to neoplasm.