In this study, we describe the construction of a novel antibody–chemokine fusion protein, called IP10-EGFRvIIIscFv, for targeting tumor cells and triggering a specific immune response against tumors by linking the chemokine IP-10 to a scFv fragment specific for EGFRvIII combined with EGFRvIII-specific DCs. Here, CXCL10 is linked to neoplasm.