MAPK3 and ovarian carcinoma: We showed that silencing of EGFR with this siRNA in ovarian cancer cells decreased phosphorylation of AKT at Ser473 and ERK1/2 at Thr202/Tyr204 on Western Blotting, but there was no significant change in phosphorylation of AKT at Thr308 (Figure 6B, Figure S3 (D-E)).