Wnt ligand is reported to trigger proliferation through extracellular signal-related kinases (ERKs, the classical MAPKs) in fibroblasts (Yun et al., 2005), and β-catenin can induce epidermal growth factor receptor (EGFR) gene expression in hepatocellular (Latasa et al., 2012) and prostate carcinoma (Guturi et al., 2012) cells. Here, EGFR is linked to prostate carcinoma.