Finally, several genes coding for phospholipid metabolism related enzymes were regulated under infection, such as CER3, which is essential for epidermal lipid homeostasis [46], AGPAT9, and PGS1, while LCLAT1 and CDS1 were downregulated, suggesting the relevance of phospholipid metabolism in signaling and membrane homeostasis during T. cruzi early infection. Here, CDS1 is linked to infection.