BAX and breast carcinoma: Recently, it has been reported that the anticancer effects of carvacrol in metastatic breast cancer cells (MDA-MB231) were based on the activation of the classical apoptosis response, including decrease in mitochondrial membrane potential and increase in cytochrome c release from mitochondria, decrease in Bcl-2/Bax ratio, increase in caspase activity, and cleavage of PARP and fragmentation of DNA, which belong to the mitochondrial pathway of the apoptosis [25].