A study by Suzuki et al. also observed similar correlations between IGFBP7 methylation and BRAF mutation and p16 methylation and CIMP and an inverse correlation with KRAS mutation in colorectal tumours. IGFBP7 methylation was also detected in 18% of conventional adenomas, which was similar to our results (19%) [40]. This evidence concerns the gene BRAF and colorectal neoplasm.