Our hypotheses were that (a) CIMP will be rare in HPs and CAs but will be more prevalent in SSAs which are the immediate precursors to CIMP-H and MSI-H CRC and (b) CIMP will be more prevalent in proximal lesions and (c) will be associated with the methylation of genes whose silencing is thought to play a functional role in the serrated neoplastic pathway (MLH1, p16, and IGFBP7) [21]. Here, IGFBP7 is linked to colorectal carcinoma.