This notion is also supported by the increased expression of enzymes involved in nucleotide biosynthesis in DBA individuals (Halperin and Freedman, 1989) and by the increased expression of genes encoding factors involved in ribosome biogenesis in zebrafish Rpl11 mutants, these include PolI and PolII, Ddx family, and nucleolar factors among others (Danilova et al., 2011). The gene discussed is AKR1C3; the disease is Diamond-Blackfan anemia.