This notion is also supported by the increased expression of enzymes involved in nucleotide biosynthesis in DBA individuals (Halperin and Freedman, 1989) and by the increased expression of genes encoding factors involved in ribosome biogenesis in zebrafish Rpl11 mutants, these include PolI and PolII, Ddx family, and nucleolar factors among others (Danilova et al., 2011). This evidence concerns the gene POLI and Diamond-Blackfan anemia.