Furthermore, considering the vascular leakage inhibiting activity of Sac-1004 in pathological conditions and its activity against different agonists (VEGF, thrombin, histamine etc.), Sac-1004 could probably be applied for other vascular leakage related diseases such as ischemia/ reperfusion injury, stroke, acute lung injury, acute and chronic inflammation, diabetic retinopathy, macular degeneration etc. This evidence concerns the gene VEGFA and macular degeneration.