VASH1 and neoplasm: Downregulation of this signaling increases tumor oxygenation, increases pericyte coverage, and improves pathologically thickened basement membranes, at least during a time window [8, 34]; Semaphorin3A improves pericyte coverage of blood vessels and restores normoxia [35]; Vasohibin-1 blocks sprouting angiogenesis resulting in mature vessels covered by mural cells [36].