In this microenvironment, cancer, endothelial, and stromal cells secrete various growth factors (e.g., vascular endothelial growth factor [VEGF], angiopoietin [Ang]2, platelet derived growth factor (PDGF), placental growth factor, transforming growth factor (TGF)-alpha, and hepatocyte growth factor), establishing an endless loop of non-productive angiogenesis [2, 3]. The gene discussed is VEGFA; the disease is cancer.