Of note, most of these studies showed that simultaneous targeting of two different pathways induced some responses in KRAS mutant CRC mouse models, albeit rarely with overt tumor regressions [51] (see Table 1); most of these approaches are currently under evaluation in phase I/II clinical trials (NCT01085331, http://clinicaltrials.gov/ct2/show/NCT01085331?term=NCT01085331&rank=1; NCT01390818, http://clinicaltrials.gov/ct2/results?term=NCT01390818&Search=Search; NCT02039336, http://clinicaltrials.gov/ct2/show/NCT02039336?term=NCT02039336&rank=1). The gene discussed is KRAS; the disease is neoplasm.