Our data implicating tumor cell-produced MMP9 as a molecular driver of metastatic progression in models of basal-like triple negative breast cancer, in combination with the meta-analyses showing that MMP9 is most highly upregulated in these types of tumors, suggests MMP9 as a druggable target that may prove useful in these patients for whom established targeted therapies are of minimal benefit. The gene discussed is MMP9; the disease is neoplasm.