CD40LG and rheumatoid arthritis: However, excluded patients were slightly younger (45 vs. 49 years, p = 0.002), fewer were positive for ACPA (24.5% vs. 45.6%, p<0.0001) and IgM rheumatoid factor (IgM RF) (36.2% vs. 50.4%, p = 0.0001) and fewer met the 1987 American College of Rheumatology (ACR) RA criteria (61.1% vs. 76.1%, p<0.0001).