Consistent with the hypothesis that AKT-mTOR may be part of the DDR barrier, we observed an activation of pAkt, and pS6 in the MCF10A progression model with levels increasing in MCF10.AT1, MCF10.DCIS and MCF10.CA1d as compared to MCF10A (P) [fig. Here, MTOR is linked to ductal breast carcinoma in situ.