Studies of Young et al and Kim et al [28]–[30] showed that the more advanced stages of breast cancer over express several other oncogenic and signaling proteins such as IGF-1R, Cyclin D1, c myc, pERK, Stat3, and Pak4; some of which are known activators of Akt-mTOR pathway. This evidence concerns the gene EIF2AK3 and breast carcinoma.