Therefore, considering that Hippo pathway is a cascade of phosphorylation events which inhibits YAP1, we can speculate that in YAP1-amplified cancer cell lines the transient YAP1 downregulation, by mimicking an over-activation of Hippo pathway, induces a feedback loop function on Hippo pathway components, that tends to counterbalance the YAP1 silencing. Here, YAP1 is linked to cancer.