YAP1 and hepatocellular carcinoma: YAP1 resulted amplified in human hepatocellular carcinoma and cooperated with myc oncogene to induce tumor growth in nude mice [12]. In non-transformed mammary cells YAP1 ectopic overexpression induces alterations typical of a transformed phenotypes, namely anchorage-independent growth, EMT, growth factor independent proliferation, activation of AKT/ERK and inhibition of apoptosis [13].