In particular, in our experiments, we exploited RNA interference strategies to silence YAP1 in cancer cell lines (Ca-Ski, EKVX and RO82) that carried 11q22 copy number amplification and YAP1 overexpression and compared YAP1 silenced cells and control cells for gene expression profiling, cell proliferation tumorigenic potential, cell migration and response to genotoxic stress. The gene discussed is YAP1; the disease is cancer.