Tilan et al. recently demonstrated that, in addition to upregulating VEGF, hypoxia also enhances Ewing sarcoma angiogenesis through induction of the neuropeptide Y (NPY) receptor Y2R in endothelial cells while also increasing the release of its ligand, NPY3-36, from Ewing sarcoma cells [44]. Here, NPY is linked to Ewing sarcoma.