Against this background, we evaluated the expression of Eya2 in normal pancreas and in pancreatic cancer tissues and cell lines, examined the methylation and histone acetylation status of its promoter and determined the consequences of stably expressing EYA2 in pancreatic cancer cells including effects on tumor growth and metastases in an orthotopic model and effects on gene expression. This evidence concerns the gene EYA2 and neoplasm.