We found the EYA2 CpG island (Figure 2B) unmethylated in HPDE and the EYA2-expressing cancer cell line, Panc215, but it was methylated at most or all CpGs sequenced in the non-expressing Panc2.8 and A38-5 cell lines, respectively (Figure 2C), and remained unmethylated in the non-expressing Panc2.5 and Panc3.014 cells. Here, EYA2 is linked to cancer.