Analysis of histone marks in pancreatic cancer cell lines by chromatin immunoprecipitation indicated a correlation between EYA2 silencing and histone H3 deacetylation of the EYA2 promoter (Figure 2D) where non-expressing cells showed a significant enrichment of the inactivating histone mark, 3mK27H3, while high-expressing cells showed a significant enrichment in acetylation of histone H3. The gene discussed is EYA2; the disease is familial pancreatic carcinoma.