EYA2 and colorectal neoplasm: On the other hand, enforced expression of Eya2 has been shown to trigger apoptosis in IL-3-dependant myeloid cells [23], and EYA2 has been found to be aberrantly hypermethylated in most colorectal neoplasms [24], indicating the potential for EYA2 promoter methylation as a marker of tumorigenesis.