In contrast to the tumor suppressive functions of EYA2 in pancreatic cancers, Zhang and collaborators [21] found that EYA2 is up-regulated in epithelial ovarian cancer, promotes tumor growth and its overexpression is associated with short overall survival and Farabaugh et al found EYA2 had prometastatic functions in breast cancer [22]. This evidence concerns the gene EYA2 and breast cancer.