CASP3 and hepatocellular carcinoma: Recently, GA has been reported to induce ROS accumulation in human hepatoma SMMC-7721 cells, the ovarian cancer cell line (SKOV-3) and multiple myeloma RPMI-8226 cells, contributing to apoptosis by triggering the mitochondrial signaling pathway and activating caspase-3 [40], [41], [42].