We also found that a combined phenotype of Th2 (IL-5 and IL-13) and regulatory (IL-10) cytokine responses to GST (PC2) was lowest in children aged 10–12 years in whom infection intensity and prevalence are peaking, suggesting that this may be a particularly dynamic period in terms of GST exposure and development of GST-specific cellular immune responses. This evidence concerns the gene IL10 and infection.