In view of the high levels of IP-10 produced compared to IFN-γ [22], [28] and since, in contrast to IFN-γ, IP-10 is not affected by low CD4 counts in TB patients with HIV [28], we investigated whether IP-10, as an alternative to IFN-γ, can be applied as a pro-inflammatory biomarker. This evidence concerns the gene IFNG and tuberculosis.