As mentioned above, we still need to take advantage of classical and emerging biomarker to interpret the heterogeneity so that the molecular classification can further improve, providing new clue for prognosis, treatment selection.In conclusion, our results revealed that ATRX mRNA expression alteration plays a critical role in astrocytic tumors and a new molecular stratification can serve as a useful addition to conventional glioma classification. Here, ATRX is linked to astrocytic tumor.